Stanley Leung, BA

Specialist
Medicine
Publications: 

Epigenetic and transcriptional programs define osteosarcoma subtypes and establish targetable vulnerabilities.

Cancer discovery

Lopez-Fuentes E, Clugston AS, Lee AG, Sayles LC, Sorensen N, Pons Ventura MV, Leung SG, Dinh T, Breese MR, Sweet-Cordero EA

Consistently processed RNA sequencing data from 50 sources enriched for pediatric data.

Scientific data

Beale HC, Learned K, Kephart ET, Lyle AG, van den Bout A, McCabe M, Echandia-Monroe K, Khare MJ, Huang EY, Jariwala S, Antilla R, Cheney A, Lee AG, Sayles LC, Leung SG, Vasquez YA, Sanders L, Haussler D, Salama SR, Sweet-Cordero EA, Vaske OM

Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity.

Nature communications

Liu T, Zhang M, Farsh T, Li H, Kishishita A, Barpanda A, Leung SG, Zhu J, Jung H, Hua JT, Zhu X, Kim AB, Goo YA, Son M, Kim J, Subramanian A, Sjöström M, Fuh KC, Chapman JS, Carnevale J, Gilbert LA, Lakkaraju A, Bruno PM, Quigley D, Wiita AP, Feng FY, DeSelm CJ

Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach.

Clinical cancer research : an official journal of the American Association for Cancer Research

Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA

Pre-and post-HSCT use of TKI therapy for fusion-driven B-ALL: A case series of five pediatric, adolescent and young adult patients.

Cancer reports (Hoboken, N.J.)

Shumock SS, Temple WC, Marinoff A, Aaronson K, Southworth E, Xirenayi S, Lee AG, Leung SG, Sweet-Cordero EA, Hermiston M, Higham C, Stieglitz E

UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma.

Nature communications

Kostyrko K, Román M, Lee AG, Simpson DR, Dinh PT, Leung SG, Marini KD, Kelly MR, Broyde J, Califano A, Jackson PK, Alejandro Sweet-Cordero E

Development and characterization of new patient-derived xenograft (PDX) models of osteosarcoma with distinct metastatic capacities.

bioRxiv : the preprint server for biology

Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MAV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA

A comprehensive circulating tumor DNA assay for detection of translocation and copy number changes in pediatric sarcomas.

Molecular cancer therapeutics

Shah AT, Azad TD, Breese MR, Chabon JJ, Hamilton EG, Straessler K, Kurtz DM, Leung SG, Spillinger A, Liu HY, Behroozfard IH, Wittber FM, Hazard FK, Cho SJ, Daldrup-Link HE, Vo KT, Rangaswami A, Pribnow A, Spunt SL, Lacayo NJ, Diehn M, Alizadeh AA, Sweet-Cordero EA

NUP98-NSD1 Driven MDS/MPN in Childhood Masquerading as JMML.

Journal of pediatric hematology/oncology

Behnert A, Lee AG, Young EP, Breese MR, Leung SG, Behroozfard I, Maruffi M, Sweet-Cordero EA, Dvorak CC, Chu J, Stieglitz E

Complete Response to PD-1 Inhibition in an Adolescent With Relapsed Clear Cell Adenocarcinoma of the Cervix Predicted by Neoepitope Burden and APOBEC Signature.

JCO precision oncology

Levinson A, Lee AG, Martell HJ, Breese MR, Zaloudek C, Van Ziffle J, Laguna B, Leung SG, Chen MD, Chen LM, Pfeil J, Ladwig NR, Shah AT, Behroozfard I, Rao AA, Salama SR, Sweet-Cordero EA, Stieglitz E

Hydra: A mixture modeling framework for subtyping pediatric cancer cohorts using multimodal gene expression signatures.

PLoS computational biology

Pfeil J, Sanders LM, Anastopoulos I, Lyle AG, Weinstein AS, Xue Y, Blair A, Beale HC, Lee A, Leung SG, Dinh PT, Shah AT, Breese MR, Devine WP, Bjork I, Salama SR, Sweet-Cordero EA, Haussler D, Vaske OM

Antitumor activity of an engineered decoy receptor targeting CLCF1-CNTFR signaling in lung adenocarcinoma.

Nature medicine

Kim JW, Marquez CP, Kostyrko K, Koehne AL, Marini K, Simpson DR, Lee AG, Leung SG, Sayles LC, Shrager J, Ferrer I, Paz-Ares L, Gephart MH, Vicent S, Cochran JR, Sweet-Cordero EA

Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor.

Cold Spring Harbor molecular case studies

Sanders LM, Rangaswami A, Bjork I, Lam DL, Beale HC, Kephart ET, Durbin A, Learned K, Currie R, Lyle AG, Pfeil J, Shah AT, Lee AG, Leung SG, Behroozfard IH, Breese MR, Peralez J, Hazard FK, Lacayo N, Spunt SL, Haussler D, Salama SR, Sweet-Cordero EA, Vaske OM

Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer.

JAMA network open

Vaske OM, Bjork I, Salama SR, Beale H, Tayi Shah A, Sanders L, Pfeil J, Lam DL, Learned K, Durbin A, Kephart ET, Currie R, Newton Y, Swatloski T, McColl D, Vivian J, Zhu J, Lee AG, Leung SG, Spillinger A, Liu HY, Liang WS, Byron SA, Berens ME, Resnick AC, Lacayo N, Spunt SL, Rangaswami A, Huynh V, Torno L, Plant A, Kirov I, Zabokrtsky KB, Rassekh SR, Deyell RJ, Laskin J, Marra MA, Sender LS, Mueller S, Sweet-Cordero EA, Goldstein TC, Haussler D

Trends in the US and Canadian Pathologist Workforces From 2007 to 2017.

JAMA network open

Metter DM, Colgan TJ, Leung ST, Timmons CF, Park JY

Genome-Informed Targeted Therapy for Osteosarcoma.

Cancer discovery

Sayles LC, Breese MR, Koehne AL, Leung SG, Lee AG, Liu HY, Spillinger A, Shah AT, Tanasa B, Straessler K, Hazard FK, Spunt SL, Marina N, Kim GE, Cho SJ, Avedian RS, Mohler DG, Kim MO, Dubois SG, Hawkins DS, Sweet-Cordero EA

Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice.

Oncotarget

Yue Y, Leung SG, Liu Y, Huang Y, Grundt K, Østvold AC, Jen KY, Schild D, Mao JH, Wiese C

NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.

Nucleic acids research

Parplys AC, Zhao W, Sharma N, Groesser T, Liang F, Maranon DG, Leung SG, Grundt K, Dray E, Idate R, Østvold AC, Schild D, Sung P, Wiese C

Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry.

Molecular cell

Zhao W, Vaithiyalingam S, San Filippo J, Maranon DG, Jimenez-Sainz J, Fontenay GV, Kwon Y, Leung SG, Lu L, Jensen RB, Chazin WJ, Wiese C, Sung P

RAD51AP1-deficiency in vertebrate cells impairs DNA replication.

DNA repair

Parplys AC, Kratz K, Speed MC, Leung SG, Schild D, Wiese C

Micronucleus formation in human keratinocytes is dependent on radiation quality and tissue architecture.

Environmental and molecular mutagenesis

Snijders AM, Mannion BJ, Leung SG, Moon SC, Kronenberg A, Wiese C

Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair.

The Journal of biological chemistry

Dunlop MH, Dray E, Zhao W, San Filippo J, Tsai MS, Leung SG, Schild D, Wiese C, Sung P